P846 Epidemiological and Clinical Characteristics of Inflammatory Bowel Diseases in Patients from Greece

Abstract Background There are few reports from Greece about the epidemiological and clinical features of inflammatory bowel diseases (IBD), which were mainly evaluated in retrospective studies with data collection hospital registries. We aimed to determine profile as well detect any differences between patients Crohn’s disease (CD) ulcerative colitis (UC), based on retrospectively-prospectively collected a cohort IBD followed daily practice. Methods Patients biopsy-confirmed aged 10–90 years old included study. A comprehensive questionnaire was used collect each site visit July 2018 until March 2022. Logistic regression analysis chi-squared test compare frequency characteristics UC CD. Results 300 diagnosed (180 CD, 113 UC, 7 indeterminate colitis). The median age 42 years. onset CD group observed 17 40 majority (58%). Ileocolonic location present 70% patients; 39% had stricturing behavior 29% perianal (abscesses fistulas). developed more often aphthous stomatitis (34%) than (13%, OR 3.45; 95% CI: 1.76-6.78; P< .001). 20-fold increased risk undergo surgical procedure (OR 19.87; 6.03-65.48; .001), enterectomy (26%), shown table 1. At study entry, C-reactive protein (CRP) elevation frequently compared 1.93; 1.04-3.59; .05). Most extensive (56%). Mesalamine predominantly (81% vs 46% .005), sulfasalazine thiopurines (60-70% 9-13% 2. most commonly anti-TNF agent Infliximab, (24% 4% 0.12; 0.04-0.34; Adalimumab 12% Vedolizumab 8%. Around complicated received Ustekinumab. Tofacitinib 2% severe extraintestinal manifestations. Enteral diet (Modulen®) 6% only pancolitis. Conclusion In this retrospective-prospective IBD, significantly higher developing levels CRP. also required treatment agents immunosuppressants, procedure, enterectomy.